Generally, biosensors use molecular probes such as DNA, RNA, enzymes and antibodies to capture specific molecules that scientists and engineers want to examine.

These probes offer selectivity, but have many limitations. The reagents that must be used are expensive. The probes have limited life spans, and it requires highly trained technicians to operate them. Above all, it is almost impossible to find probes to target each kind of molecule researchers want to study.

Chae is solving the problem by utilizing nature’s “smart system.” His protein proposed probe-less biosensor has high selectivity, and is packaged in a way that makes it resistant to environmental changes such as temperature, humidity and vibration. This biosensor is a new concept that Chae says can lead to new and improved instruments for biological research.